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For those Questions, Why Don't I feel High off medibles, Why Do I get So Blown out on medibles Here's a quick summary of the different variants: AA - Most efficient CYP2C9 enzyme. Breaks down THC most fully and rapidly. Likely to experience the least amount of drowsiness from pot. Gets less high from edibles, high from smoking or edibles shorter in duration. AC - Intermediate between AA and CC CC - Least efficient CYP2C9 enzyme. Does not break down THC as completely. Likely to experience the most amount of drowsiness from pot. Gets WAY more high from edibles, high from smoking or edibles longer in duration. How Your DNA Affects Your Response to Cannabis - The CYP2C9 Gene